| Post Translational Modifications | Phosphorylated on serine and threonine residues. Phosphorylated on Thr-1648 by Rho-kinase. Its phosphorylation by Rho-kinase inhibits its guanine nucleotide exchange activity, its interaction with MAP1A, MAP1B, PARP1 and YWHAE and reduces its ability to promote neurite growth. |
| Function | Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane. Activates specifically RAC1, but not CDC42 and RHOA. |
| Protein Name | Rho Guanine Nucleotide Exchange Factor Tiam2Sif And Tiam1-Like Exchange FactorT-Lymphoma Invasion And Metastasis-Inducing Protein 2Tiam-2 |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-1989781Reactome: R-HSA-416482Reactome: R-HSA-9013149 |
| Cellular Localisation | CytoplasmCell ProjectionLamellipodiumFilopodiumGrowth ConeNeuron ProjectionPerikaryon |
| Alternative Antibody Names | Anti-Rho Guanine Nucleotide Exchange Factor Tiam2 antibodyAnti-Sif And Tiam1-Like Exchange Factor antibodyAnti-T-Lymphoma Invasion And Metastasis-Inducing Protein 2 antibodyAnti-Tiam-2 antibodyAnti-TIAM2 antibodyAnti-KIAA2016 antibodyAnti-STEF antibody |
Information sourced from Uniprot.org
