| Post Translational Modifications | Auto-ubiquitinated and ubiquitinated in the presence of RNF11 and UBE2D1. Ubiquitinated by the SCF(FBXL15) complex and TTC3, leading to its degradation by the proteasome. 'Lys-48'-linked polyubiquitination mediated by TRAF4 at Lys-119 leads to SMURF2 proteasomal degradation. |
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD7 to trigger SMAD7-mediated transforming growth factor beta/TGF-beta receptor ubiquitin-dependent degradation, thereby down-regulating TGF-beta signaling. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with AIMP1. Also forms a stable complex with TGF-beta receptor-mediated phosphorylated SMAD1, SMAD2 and SMAD3, and targets SMAD1 and SMAD2 for ubiquitination and proteasome-mediated degradation. SMAD2 may recruit substrates, such as SNON, for ubiquitin-dependent degradation. Negatively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation. (Microbial infection) In case of filoviruses Ebola/EBOV and Marburg/MARV infection, the complex formed by viral matrix protein VP40 and SMURF2 facilitates virus budding. |
| Protein Name | E3 Ubiquitin-Protein Ligase Smurf2Hsmurf2Hect-Type E3 Ubiquitin Transferase Smurf2Smad Ubiquitination Regulatory Factor 2Smad-Specific E3 Ubiquitin-Protein Ligase 2 |
| Database Links | Reactome: R-HSA-201451Reactome: R-HSA-2173788Reactome: R-HSA-2173795Reactome: R-HSA-4608870Reactome: R-HSA-4641257Reactome: R-HSA-5632684Reactome: R-HSA-5689880Reactome: R-HSA-8941858Reactome: R-HSA-983168 |
| Cellular Localisation | NucleusCytoplasmCell MembraneMembrane RaftCytoplasmic In The Presence Of Smad7Colocalizes With Cav1Smad7 And Tgf-Beta Receptor In Membrane Rafts |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Smurf2 antibodyAnti-Hsmurf2 antibodyAnti-Hect-Type E3 Ubiquitin Transferase Smurf2 antibodyAnti-Smad Ubiquitination Regulatory Factor 2 antibodyAnti-Smad-Specific E3 Ubiquitin-Protein Ligase 2 antibodyAnti-SMURF2 antibody |
Information sourced from Uniprot.org
