| Host: |
Mouse |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Recombinant-Sarm1 Mouse mAb (1-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S5113MM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:2000-1:4000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Sarm1 |
| Gene ID: |
237868 |
| Uniprot ID: |
SARM1_MOUSE |
| Immunogen Region: |
1-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of mouse Sarm1 (NP_766383.2). |
| Immunogen Sequence: |
MVLTLLFSAYKLCRFFTMSG PRPGADRLTVPGPDRSGGAS PWWAAGGRGSREVSPGVGTE VQGALERSLPELQQALSELK QASAARAVGAGLAEVFQLVE |
| Tissue Specificity | Widely expressed in the brain and neurons (at protein level). Expressed in photoreceptor cells of the neural retina. |
| Post Translational Modifications | Phosphorylation at Ser-548 by JNK kinases (MAPK8, MAPK9 and /or MAPK10) enhance the NAD(+) hydrolase (NADase) activity. Phosphorylation at Ser-548 and subsequent activation takes place in response to oxidative stress conditions and inhibits mitochondrial respiration. |
| Function | NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site. Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide.NAD(+) cleavage promoting cytoskeletal degradation and axon destruction. Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules. Can activate neuronal cell death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38. |
| Protein Name | Nad(+ Hydrolase Sarm1Nadase Sarm1Nadp(+ Hydrolase Sarm1Sterile Alpha And Tir Motif-Containing Protein 1 |
| Database Links | Reactome: R-MMU-166166Reactome: -MMU-936964Reactome: -MMU-937041Reactome: -MMU-937072 |
| Cellular Localisation | CytoplasmCell ProjectionAxonDendriteSynapseMitochondrionAssociated With Microtubules |
| Alternative Antibody Names | Anti-Nad(+ Hydrolase Sarm1 antibodyAnti-Nadase Sarm1 antibodyAnti-Nadp(+ Hydrolase Sarm1 antibodyAnti-Sterile Alpha And Tir Motif-Containing Protein 1 antibodyAnti-Sarm1 antibodyAnti-Kiaa0524 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
