| Function | Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates. |
| Protein Name | Pancreas Transcription Factor 1 Subunit AlphaPancreas-Specific Transcription Factor 1aBhlh Transcription Factor P48P48 Dna-Binding Subunit Of Transcription Factor Ptf1Ptf1-P48 |
| Cellular Localisation | NucleusCytoplasmIn The Cytoplasm Loses Its Ability To Form The Ptf1 Complex |
| Alternative Antibody Names | Anti-Pancreas Transcription Factor 1 Subunit Alpha antibodyAnti-Pancreas-Specific Transcription Factor 1a antibodyAnti-Bhlh Transcription Factor P48 antibodyAnti-P48 Dna-Binding Subunit Of Transcription Factor Ptf1 antibodyAnti-Ptf1-P48 antibodyAnti-Ptf1a antibodyAnti-Ptf1p48 antibody |
Information sourced from Uniprot.org
