| Post Translational Modifications | Transiently sumoylated, preferentially conjugated to SUMO2 or SUMO3. Sumoylation causes nucleolar exclusion of PELP1 and promotes the recruitment of MDN1 to pre-60S particles. Desumoylation by SUMO isopeptidase SENP3 is needed to release both PELP1 and MDN1 from pre-ribosomes. |
| Function | Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex.the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1. May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. |
| Protein Name | Proline- - Glutamic Acid- And Leucine-Rich Protein 1Modulator Of Non-Genomic Activity Of Estrogen ReceptorTranscription Factor Hmx3 |
| Database Links | Reactome: R-HSA-6791226Reactome: R-HSA-8849473 |
| Cellular Localisation | NucleusNucleolusNucleoplasmCytoplasmMainly Found In The NucleoplasmWith Low Levels Detected In The CytoplasmAlso Found Associated With The Plasma MembraneMainly In Cytoplasm In A Subset Of Breast TumorsLocalization Is Widely Deregulated In Endometrial Cancers With Predominantly Cytoplasm Localization In High-Grade Endometrial Tumors |
| Alternative Antibody Names | Anti-Proline- - Glutamic Acid- And Leucine-Rich Protein 1 antibodyAnti-Modulator Of Non-Genomic Activity Of Estrogen Receptor antibodyAnti-Transcription Factor Hmx3 antibodyAnti-PELP1 antibodyAnti-HMX3 antibodyAnti-MNAR antibody |
Information sourced from Uniprot.org
