| Host: |
Rabbit |
| Applications: |
IF/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : |
Rabbit monoclonal antibody anti-Recombinant-Kinesin-Like Protein Kif2c is suitable for use in Immunofluorescence and Western Blot research applications. |
| Clonality : |
Monoclonal |
| Clone ID : |
RM2M75 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide |
| Purification: |
Protein A/G purified from cell culture supernatant |
| Dilution Range: |
IF: 1:50-1:200, WB: 1:500-1:1000 |
| Storage Instruction: |
Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
| Post Translational Modifications | Phosphorylation by AURKB, regulates association with centromeres and kinetochores and the microtubule depolymerization activity. Ubiquitinated. |
| Function | In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment. |
| Protein Name | Kinesin-Like Protein Kif2cKinesin-Like Protein 6Mitotic Centromere-Associated KinesinMcak |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2132295Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-6811434Reactome: R-HSA-68877Reactome: R-HSA-9648025Reactome: R-HSA-983189 |
| Cellular Localisation | CytoplasmCytoskeletonNucleusChromosomeCentromereKinetochoreAssociates With The Microtubule Network At The Growing Distal Tip (The Plus-End) Of MicrotubulesProbably Through Interaction With Mtus2/Tip150 And Mapre1Association With Microtubule Plus Ends Is Also Mediated By Interaction With Kif18bCentromeric Localization Requires The Presence Of Bub1 And Sgo2 |
| Alternative Antibody Names | Anti-Kinesin-Like Protein Kif2c antibodyAnti-Kinesin-Like Protein 6 antibodyAnti-Mitotic Centromere-Associated Kinesin antibodyAnti-Mcak antibodyAnti-KIF2C antibodyAnti-KNSL6 antibody |
Information sourced from Uniprot.org
