Anti-Recombinant-GLS antibody [RM1G11] (STJA0023203)

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STJA0023203
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Covered by St John's Laboratory Guarantee

Host: Rabbit
Applications: IF/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Glutaminase Kidney Isoform-Mitochondrial is suitable for use in Immunofluorescence, Immunoprecipitation and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM1G11
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: IF: 1:50-1:200
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: GLS
Gene ID: 2744
Uniprot ID: GLSK_HUMAN
Post Translational Modifications Synthesized as a 74-kDa cytosolic precursor which is proteolytically processed by the mitochondrial-processing peptidase (MPP) via a 72-kDa intermediate to yield the mature mitochondrial 68- and 65-kDa subunits.
Function Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain. Isoform 2: Lacks catalytic activity.
Protein Name Glutaminase Kidney Isoform - Mitochondrial
Gls
K-Glutaminase
L-Glutamine Amidohydrolase Cleaved Into - Glutaminase Kidney Isoform - Mitochondrial 68 Kda Chain - Glutaminase Kidney Isoform - Mitochondrial 65 Kda Chain
Database Links Reactome: R-HSA-210500
Reactome: R-HSA-5628897
Reactome: R-HSA-8964539
Cellular Localisation Isoform 1: Mitochondrion
Cytoplasm
Cytosol
The 74-Kda Cytosolic Precursor Is Translocated Into The Mitochondria And Processed Via A 72-Kda Intermediate To Yield The Mature 68- And 65-Kda Subunits
Isoform 3: Mitochondrion
Glutaminase Kidney Isoform
Mitochondrial 68 Kda Chain: Mitochondrion Matrix
Produced By The Proteolytic Processing Of The 74-Kda Cytosolic Precursor
Mitochondrial 65 Kda Chain: Mitochondrion Matrix
Alternative Antibody Names Anti-Glutaminase Kidney Isoform - Mitochondrial antibody
Anti-Gls antibody
Anti-K-Glutaminase antibody
Anti-L-Glutamine Amidohydrolase Cleaved Into - Glutaminase Kidney Isoform - Mitochondrial 68 Kda Chain - Glutaminase Kidney Isoform - Mitochondrial 65 Kda Chain antibody
Anti-GLS antibody
Anti-GLS1 antibody
Anti-KIAA0838 antibody

Information sourced from Uniprot.org

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