| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RD3 (1-195) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RD3 |
| Gene ID: |
343035 |
| Uniprot ID: |
RD3_HUMAN |
| Immunogen Region: |
1-195 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-195 of human RD3 (NP_898882.1). |
| Immunogen Sequence: |
MSLISWLRWNEAPSRLSTRS PAEMVLETLMMELTGQMREA ERQQRERSNAVRKVCTGVDY SWLASTPRSTYDLSPIERLQ LEDVCVKIHPSYCGPAILRF RQLLAEQEPEVQEVSQLFRS VLQEVLERMKQEEEAHKLTR QWSLRPRGSLATFKTRARIS PFASDIRTISEDVERDTPPP LRSWSMPEFRAPKAD |
| Tissue Specificity | Expressed in retina. Widely expressed (at protein level). In the retina the strongest immunoreactivity is detected in the inner half of the cytoplasmic portion of the photoreceptor layer, where rods and cones are found, and the external half of the outer plexiform layer (at protein level). |
| Function | Plays a critical role in the regulation of enzymes involved in nucleotide cycle in photoreceptors. Inhibits the basal catalytic activity and the GCAP-stimulated activity of GUCY2D and GUCY2F, two retinal guanylyl cyclases involved in the production of cGMP in photoreceptors. Involved in the transport of GUCY2D and GUCY2F to their target sites in the photoreceptor outer segment. Up-regulates the activity of GUK1, a kinase that also plays an essential role for recycling GMP and indirectly, cGMP. Plays an important role for the survival of rods and cones in the retina. |
| Protein Name | Protein Rd3Retinal Degeneration Protein 3 |
| Cellular Localisation | Cell ProjectionCiliumPhotoreceptor Outer SegmentPhotoreceptor Inner SegmentEndosomeNucleusCytoplasmPerinuclear RegionColocalizes With Gucy2e And Gucy2f In Rods And Cones PhotoreceptorsColocalizes With Guk1 In Photoreceptor Inner Segments And To A Lesser Extent In The Outer Plexiform LayerStrong Dot-Like Perinuclear Staining In The Epithelial Cells |
| Alternative Antibody Names | Anti-Protein Rd3 antibodyAnti-Retinal Degeneration Protein 3 antibodyAnti-RD3 antibodyAnti-C1orf36 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
