| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RD3 |
| Gene ID: | 343035 |
| Uniprot ID: | RD3_HUMAN |
| Immunogen Region: | 1-195 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-195 of human RD3 (NP_898882.1). |
| Immunogen Sequence: | MSLISWLRWNEAPSRLSTRS PAEMVLETLMMELTGQMREA ERQQRERSNAVRKVCTGVDY SWLASTPRSTYDLSPIERLQ LEDVCVKIHPSYCGPAILRF RQLLAEQEPEVQEVSQLFRS VLQEVLERMKQEEEAHKLTR QWSLRPRGSLATFKTRARIS PFASDIRTISEDVERDTPPP LRSWSMPEFRAPKAD |
| Tissue Specificity | Expressed in retina. Widely expressed (at protein level). In the retina the strongest immunoreactivity is detected in the inner half of the cytoplasmic portion of the photoreceptor layer, where rods and cones are found, and the external half of the outer plexiform layer (at protein level). |
| Function | Plays a critical role in the regulation of enzymes involved in nucleotide cycle in photoreceptors. Inhibits the basal catalytic activity and the GCAP-stimulated activity of GUCY2D and GUCY2F, two retinal guanylyl cyclases involved in the production of cGMP in photoreceptors. Involved in the transport of GUCY2D and GUCY2F to their target sites in the photoreceptor outer segment. Up-regulates the activity of GUK1, a kinase that also plays an essential role for recycling GMP and indirectly, cGMP. Plays an important role for the survival of rods and cones in the retina. |
| Protein Name | Protein Rd3 Retinal Degeneration Protein 3 |
| Cellular Localisation | Cell Projection Cilium Photoreceptor Outer Segment Photoreceptor Inner Segment Endosome Nucleus Cytoplasm Perinuclear Region Colocalizes With Gucy2e And Gucy2f In Rods And Cones Photoreceptors Colocalizes With Guk1 In Photoreceptor Inner Segments And To A Lesser Extent In The Outer Plexiform Layer Strong Dot-Like Perinuclear Staining In The Epithelial Cells |
| Alternative Antibody Names | Anti-Protein Rd3 antibody Anti-Retinal Degeneration Protein 3 antibody Anti-RD3 antibody Anti-C1orf36 antibody |
Information sourced from Uniprot.org