Anti-RBPMS antibody (N-Term) (STJA0003764)

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STJA0003764-100
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Host: Rabbit
Applications: WB/IHC/ICC
Reactivity: Feline/Guinea Pig/Pig/Human/Mouse/Non-Human Primates/Rabbit/Rat/Tree Shrew/Whale/Zebrafish/Canine/Hamster
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-RBPMS (N-Term) is suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 100 ul in PBS + 0.03% Sodium Azide
Purification: This antibody was antigen affinity purified from serum.
Dilution Range: WB 1:1000
IHC 1:100-1:2000
ICC 1:200-1:500
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Rbpms
Gene ID: 19663
Uniprot ID: RBPMS_MOUSE
Immunogen Region: N-Term
Immunogen: Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH.
Tissue Specificity mRNA expressed in developing heart, with significantly higher expression in the atria relative to the ventricles.
Function RNA binding protein that mediates the regulation of pre-mRNA alternative splicing (AS). Acts either as activator (FLNB, HSPG2, LIPA1, MYOCD, PTPRF and PPFIBP1) or repressor (TPM1, ACTN1, ITGA7, PIEZO1, LSM14B, MBNL1 and MBML2) of splicing events on specific pre-mRNA targets. Together with RNA binding proteins RBFOX2 and MBNL1/2, activates a splicing program associated with differentiated contractile vascular smooth muscle cells (SMC) by regulating AS of numerous pre-mRNA involved in actin cytoskeleton and focal adhesion machineries, suggesting a role in promoting a cell differentiated state. Binds to introns, exons and 3'-UTR associated with tandem CAC trinucleotide motifs separated by a variable spacer region, at a minimum as a dimer. The minimal length of RNA required for RBPMS-binding tandem CAC motifs is 15 nt, with spacing ranging from 1 to 9 nt. Can also bind to CA dinucleotide repeats. Mediates repression of TPM1 exon 3 by binding to CAC tandem repeats in the flanking intronic regions, followed by higher-order oligomerization and heterotypic interactions with other splicing regulators including MBNL1 and RBFOX2, which prevents assembly of ATP-dependent splicing complexes.
Protein Name Rna-Binding Protein With Multiple Splicing
Rbp-Ms
Rbpms
Heart And Rrm Expressed Sequence
Hermes
Cellular Localisation Nucleus
Cytoplasm
Stress Granule
P-Body
Alternative Antibody Names Anti-Rna-Binding Protein With Multiple Splicing antibody
Anti-Rbp-Ms antibody
Anti-Rbpms antibody
Anti-Heart And Rrm Expressed Sequence antibody
Anti-Hermes antibody
Anti-Rbpms antibody
Anti-Hermes antibody

Information sourced from Uniprot.org