• Western blot analysis of various lysates using RBL1 Rabbit polyclonal antibody (STJ11103356) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 120s.

Anti-RBL1 antibody (100-200) (STJ11103356)

SKU:
STJ11103356

£112.50 - £522.50
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Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-RBL1 (100-200) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: RBL1
Gene ID: 5933
Uniprot ID: RBL1_HUMAN
Immunogen Region: 100-200
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100-200 of human RBL1 (NP_002886.2).
Immunogen Sequence: QFFSKMKKWMDMSNLPQEFR ERIERLERNFEVSTVIFKKY EPIFLDIFQNPYEEPPKLPR SRKQRRIPCSVKDLFNFCWT LFVYTKGNFRMIGDDLVNSY H
Post Translational Modifications Cell-cycle arrest properties are inactivated by phosphorylation on Thr-332, Ser-640, Ser-964 and Ser-975 by CDK4.
Function Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. May act as a tumor suppressor.
Protein Name Retinoblastoma-Like Protein 1
107 Kda Retinoblastoma-Associated Protein
P107
Prb1
Database Links Reactome: R-HSA-1362277
Reactome: R-HSA-1362300
Reactome: R-HSA-1538133
Reactome: R-HSA-2173796
Reactome: R-HSA-6804114
Reactome: R-HSA-69205
Reactome: R-HSA-69231
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Retinoblastoma-Like Protein 1 antibody
Anti-107 Kda Retinoblastoma-Associated Protein antibody
Anti-P107 antibody
Anti-Prb1 antibody
Anti-RBL1 antibody

Information sourced from Uniprot.org

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