• Western blot analysis of extracts of Raji cells, using RAR Beta antibody (STJ115139) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-RARB antibody (146-370) (STJ115139)

SKU:
STJ115139

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Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-RARB (146-370) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: RARB
Gene ID: 5915
Uniprot ID: RARB_HUMAN
Immunogen Region: 146-370
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 146-370 of human RAR Beta (NP_000956.2).
Immunogen Sequence: MSKESVRNDRNKKKKETSKQ ECTESYEMTAELDDLTEKIR KAHQETFPSLCQLGKYTTNS SADHRVRLDLGLWDKFSELA TKCIIKIVEFAKRLPGFTGL TIADQITLLKAACLDILILR ICTRYTPEQDTMTFSDGLTL NRTQMHNAGFGPLTDLVFTF ANQLLPLEMDDTETGLLSAI CLICGDRQDLEEPTKVDKLQ EPLLEALKIYIRKRRPSKPH MFPKI
Tissue Specificity Expressed in aortic endothelial cells (at protein level).
Function Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.
Protein Name Retinoic Acid Receptor Beta
Rar-Beta
Hbv-Activated Protein
Nuclear Receptor Subfamily 1 Group B Member 2
Rar-Epsilon
Database Links Reactome: R-HSA-383280
Reactome: R-HSA-5362517
Reactome: R-HSA-5617472
Cellular Localisation Nucleus
Cytoplasm
Isoform Beta-1: Nucleus
Isoform Beta-2: Nucleus
Isoform Beta-4: Cytoplasm
Alternative Antibody Names Anti-Retinoic Acid Receptor Beta antibody
Anti-Rar-Beta antibody
Anti-Hbv-Activated Protein antibody
Anti-Nuclear Receptor Subfamily 1 Group B Member 2 antibody
Anti-Rar-Epsilon antibody
Anti-RARB antibody
Anti-HAP antibody
Anti-NR1B2 antibody

Information sourced from Uniprot.org

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