| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RARB (146-370) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RARB |
| Gene ID: |
5915 |
| Uniprot ID: |
RARB_HUMAN |
| Immunogen Region: |
146-370 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 146-370 of human RAR Beta (NP_000956.2). |
| Immunogen Sequence: |
MSKESVRNDRNKKKKETSKQ ECTESYEMTAELDDLTEKIR KAHQETFPSLCQLGKYTTNS SADHRVRLDLGLWDKFSELA TKCIIKIVEFAKRLPGFTGL TIADQITLLKAACLDILILR ICTRYTPEQDTMTFSDGLTL NRTQMHNAGFGPLTDLVFTF ANQLLPLEMDDTETGLLSAI CLICGDRQDLEEPTKVDKLQ EPLLEALKIYIRKRRPSKPH MFPKI |
| Tissue Specificity | Expressed in aortic endothelial cells (at protein level). |
| Function | Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function. |
| Protein Name | Retinoic Acid Receptor BetaRar-BetaHbv-Activated ProteinNuclear Receptor Subfamily 1 Group B Member 2Rar-Epsilon |
| Database Links | Reactome: R-HSA-383280Reactome: R-HSA-5362517Reactome: R-HSA-5617472 |
| Cellular Localisation | NucleusCytoplasmIsoform Beta-1: NucleusIsoform Beta-2: NucleusIsoform Beta-4: Cytoplasm |
| Alternative Antibody Names | Anti-Retinoic Acid Receptor Beta antibodyAnti-Rar-Beta antibodyAnti-Hbv-Activated Protein antibodyAnti-Nuclear Receptor Subfamily 1 Group B Member 2 antibodyAnti-Rar-Epsilon antibodyAnti-RARB antibodyAnti-HAP antibodyAnti-NR1B2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
