| Function | Acts as a GEF (guanine nucleotide exchange factor) for the Rho family of small GTP-binding proteins (G proteins) that stimulates the dissociation of GDP to enable subsequent binding of GTP. Additionally, appears to chaperone the processing and/or trafficking of small GTPases containing a C-terminal polybasic region independently of GEF activity. Targets include RAP1A/RAP1B, RHOA, RHOB, RHOC, RAC1 and KRAS. Regulates mitochondrial dynamics by controlling RHOT function to promote mitochondrial fission during high calcium conditions. Able to promote the Ca(2+) release from the endoplasmic reticulum via both inositol trisphosphate (Ins3P) and ryanodine sensitive receptors leading to a enhanced mitochondrial Ca(2+) uptake. Isoform 1: Acts as a GEF (guanine nucleotide exchange factor) for unprenylated RHOA. Chaperones the entry and passage of small GTPases through the prenylation pathway. Recognizes the last amino acid in the GTPase C-terminal CAAX motif with a preference for 'Leu' over 'Met', indicating involvement in the geranylgeranylation pathway. Isoform 2: Acts as a GEF (guanine nucleotide exchange factor) for prenylated RHOA. Acts as a GEF for RHOC. Chaperones the downstream trafficking and/or processing of small newly prenylated GTPases. Escorts RAC1 to the nucleus. |
| Protein Name | Rap1 Gtpase-Gdp Dissociation Stimulator 1Exchange Factor SmggdsSmg Gds ProteinSmg P21 Stimulatory Gdp/Gtp Exchange Protein |
| Database Links | Reactome: R-HSA-9013419Reactome: R-HSA-9013425 |
| Cellular Localisation | CytoplasmCytosolEndoplasmic ReticulumMitochondrionNucleusNuclear Import Is Dependent On Complexing With A Gtpase Containing A C-Terminal Polybasic Region |
| Alternative Antibody Names | Anti-Rap1 Gtpase-Gdp Dissociation Stimulator 1 antibodyAnti-Exchange Factor Smggds antibodyAnti-Smg Gds Protein antibodyAnti-Smg P21 Stimulatory Gdp/Gtp Exchange Protein antibodyAnti-RAP1GDS1 antibodyAnti-SMGGDS antibody |
Information sourced from Uniprot.org
