| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RANBP3 |
| Gene ID: | 8498 |
| Uniprot ID: | RANB3_HUMAN |
| Immunogen Region: | 1-250 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human RANBP3 (NP_015559.2). |
| Immunogen Sequence: | MADLANEEKPAIAPPVFVFQ KDKGQKRSAGGSSPEGGEDS DREDGNYCPPVKRERTSSLT QFPPSQSEERSSGFRLKPPT LIHGQAPSAGLPSQKPKEQQ RSVLRPAVLQAPQPKALSQT VPSSGTNGVSLPADCTGAVP AASPDTAAWRSPSEAADEVC ALEEKEPQKNESSNASEEEA CEKKDPATQQAFVFGQNLRD RVKLINESVDEADMENAGHP SADTPTATNYFLQYISSSL |
| Tissue Specificity | Widely expressed with high levels in testis and heart. |
| Post Translational Modifications | Phosphorylation at Ser-126 promotes its import into the nucleus. |
| Function | Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. |
| Protein Name | Ran-Binding Protein 3Ranbp3 |
| Cellular Localisation | CytoplasmNucleusNuclear Import Is Promoted By Phosphorylation At Ser-126 And Is Dependent On Kpna4 |
| Alternative Antibody Names | Anti-Ran-Binding Protein 3 antibodyAnti-Ranbp3 antibodyAnti-RANBP3 antibody |
Information sourced from Uniprot.org