| Tissue Specificity | Expressed in brain, kidney, heart, pancreas and placenta. Not detected in skeletal muscle or liver. |
| Post Translational Modifications | Phosphorylated by AKT1.the phosphorylation alters its GEF activity. |
| Function | Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Part of the ciliary targeting complex containing Rab11, ASAP1, RAB3IP and RAB11FIP3 and ARF4 that promotes RAB3IP preciliary vesicle trafficking to mother centriole and ciliogenesis initiation. |
| Protein Name | Rab-3a-Interacting ProteinRab3a-Interacting ProteinRabin-3Rabin8Ssx2-Interacting Protein |
| Database Links | Reactome: R-HSA-5620912Reactome: R-HSA-5620916Reactome: R-HSA-5620922Reactome: R-HSA-8876198 |
| Cellular Localisation | CytoplasmNucleusCytoskeletonCell ProjectionLamellipodiumVesicleMicrotubule Organizing CenterCentrosomePredominantly Cytoplasmic But A Small Proportion Colocalizes With Ssx2 In The NucleusActivation Of Protein Kinase C Results In Redistribution To The Periphery Of Lamellipodia |
| Alternative Antibody Names | Anti-Rab-3a-Interacting Protein antibodyAnti-Rab3a-Interacting Protein antibodyAnti-Rabin-3 antibodyAnti-Rabin8 antibodyAnti-Ssx2-Interacting Protein antibodyAnti-RAB3IP antibodyAnti-RABIN8 antibody |
Information sourced from Uniprot.org
