| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PTPRK |
| Gene ID: | 5796 |
| Uniprot ID: | PTPRK_HUMAN |
| Immunogen Region: | 600-750 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 600-750 of human PTPRK (NP_001129120.1). |
| Immunogen Sequence: | EGVDASLNETATTITVLLRP AQAKGAPISAYQIVVEELHP HRTKREAGAMECYQVPVTYQ NAMSGGAPYYFAAELPPGNL PEPAPFTVGDNRTYQGFWNP PLAPRKGYNIYFQAMSSVEK ETKTQCVRIATKAAATEEPE VIPDPAKQTDR |
| Tissue Specificity | High levels in lung, brain and colon.less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma. |
| Post Translational Modifications | This protein undergoes proteolytic processing. |
| Function | Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa. |
| Protein Name | Receptor-Type Tyrosine-Protein Phosphatase KappaProtein-Tyrosine Phosphatase KappaR-Ptp-Kappa |
| Database Links | Reactome: R-HSA-182971 |
| Cellular Localisation | Cell JunctionAdherens JunctionCell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Receptor-Type Tyrosine-Protein Phosphatase Kappa antibodyAnti-Protein-Tyrosine Phosphatase Kappa antibodyAnti-R-Ptp-Kappa antibodyAnti-PTPRK antibodyAnti-PTPK antibody |
Information sourced from Uniprot.org