| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Ubiquitinated by the ECS (Elongin BC-CUL2/5-SOCS-box protein)/LRR1 E3 ligase complex and subsequently targeted to proteasomal degradation. |
| Function | Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. |
| Protein Name | Tyrosine-Protein Phosphatase Non-Receptor Type 14Protein-Tyrosine Phosphatase Pez |
| Database Links | Reactome: R-HSA-9008059 |
| Cellular Localisation | CytoplasmCytoskeletonNucleusTranslocation Into The Nucleus Is Associated With Induction Of Cell ProliferationPartially Colocalized With Actin Filaments At The Plasma Membrane |
| Alternative Antibody Names | Anti-Tyrosine-Protein Phosphatase Non-Receptor Type 14 antibodyAnti-Protein-Tyrosine Phosphatase Pez antibodyAnti-PTPN14 antibodyAnti-PEZ antibodyAnti-PTPD2 antibody |
Information sourced from Uniprot.org
