| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PTPN14 |
| Gene ID: |
5784 |
| Uniprot ID: |
PTN14_HUMAN |
| Immunogen Region: |
650-810 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 650-810 of human PTPN14 (NP_005392.2). |
| Immunogen Sequence: |
VRGMEAMTLKSLHLPMARRN TLREQGPPEEGSGSHEVPQL PQYHHKKTFSDATMLIHSSE SEEEEEEAPESVPQIPMLRE KMEYSAQLQAALARIPNKPP PEYPGPRKSVSNGALRQDQA SLPPAMARARVLRHGPAKAI SMSRTDPPAVNGASLGPSIS E |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Ubiquitinated by the ECS (Elongin BC-CUL2/5-SOCS-box protein)/LRR1 E3 ligase complex and subsequently targeted to proteasomal degradation. |
| Function | Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. |
| Protein Name | Tyrosine-Protein Phosphatase Non-Receptor Type 14Protein-Tyrosine Phosphatase Pez |
| Database Links | Reactome: R-HSA-9008059 |
| Cellular Localisation | CytoplasmCytoskeletonNucleusTranslocation Into The Nucleus Is Associated With Induction Of Cell ProliferationPartially Colocalized With Actin Filaments At The Plasma Membrane |
| Alternative Antibody Names | Anti-Tyrosine-Protein Phosphatase Non-Receptor Type 14 antibodyAnti-Protein-Tyrosine Phosphatase Pez antibodyAnti-PTPN14 antibodyAnti-PEZ antibodyAnti-PTPD2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
