| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PTN (1-50) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PTN |
| Gene ID: |
5764 |
| Uniprot ID: |
PTN_HUMAN |
| Immunogen Region: |
1-50 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-50 of human PTN (P21246). |
| Immunogen Sequence: |
MQAQQYQQQRRKFAAAFLAF IFILAAVDTAEAGKKEKPEK KVKKSDCGEW |
| Tissue Specificity | Osteoblast and brain. |
| Post Translational Modifications | Phosphorylated by NEK6. |
| Function | Secreted growth factor that mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors. Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups. Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone. Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation. Binds PTPRZ1, leading to neutralization of the negative charges of the CS chains of PTPRZ1, inducing PTPRZ1 clustering, thereby causing the dimerization and inactivation of its phosphatase activity leading to increased tyrosine phosphorylation of each of the PTPRZ1 substrates like ALK, CTNNB1 or AFAP1L2 in order to activate the PI3K-AKT pathway. Through PTPRZ1 binding controls oligodendrocyte precursor cell differentiation by enhancing the phosphorylation of AFAP1L2 in order to activate the PI3K-AKT pathway. Forms a complex with PTPRZ1 and integrin alpha-V/beta-3 (ITGAV:ITGB3) that stimulates endothelial cell migration through SRC dephosphorylation and activation that consequently leads to ITGB3 'Tyr-773' phosphorylation. In adult hippocampus promotes dendritic arborization, spine development, and functional integration and connectivity of newborn granule neurons through ALK by activating AKT signaling pathway. Binds GPC2 and chondroitin sulfate proteoglycans (CSPGs) at the neuron surface, leading to abrogation of binding between PTPRS and CSPGs and neurite outgrowth promotion. Binds SDC3 and mediates bone formation by recruiting and attaching osteoblasts/osteoblast precursors to the sites for new bone deposition. Binds ALK and promotes cell survival and cell proliferation through MAPK pathway activation. Inhibits proliferation and enhances differentiation of neural stem cells by inhibiting FGF2-induced fibroblast growth factor receptor signaling pathway. Mediates regulatory mechanisms in normal hemostasis and in hematopoietic regeneration and in maintaining the balance of myeloid and lymphoid regeneration. In addition may play a role in the female reproductive system, auditory response and the progesterone-induced decidualization pathway. |
| Protein Name | PleiotrophinPtnHeparin-Binding Brain MitogenHbbmHeparin-Binding Growth Factor 8Hbgf-8Heparin-Binding Growth-Associated MoleculeHb-GamHeparin-Binding Neurite Outgrowth-Promoting FactorHbnfHeparin-Binding Neurite Outgrowth-Promoting Factor 1Hbnf-1Osteoblast-Specific Factor 1Osf-1 |
| Database Links | Reactome: R-HSA-201556 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Pleiotrophin antibodyAnti-Ptn antibodyAnti-Heparin-Binding Brain Mitogen antibodyAnti-Hbbm antibodyAnti-Heparin-Binding Growth Factor 8 antibodyAnti-Hbgf-8 antibodyAnti-Heparin-Binding Growth-Associated Molecule antibodyAnti-Hb-Gam antibodyAnti-Heparin-Binding Neurite Outgrowth-Promoting Factor antibodyAnti-Hbnf antibodyAnti-Heparin-Binding Neurite Outgrowth-Promoting Factor 1 antibodyAnti-Hbnf-1 antibodyAnti-Osteoblast-Specific Factor 1 antibodyAnti-Osf-1 antibodyAnti-PTN antibodyAnti-HBNF1 antibodyAnti-NEGF1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
