| Post Translational Modifications | MMP14 cleaves PTK7 between Pro-621 and Leu-622 generating an N-terminal soluble (70 kDa) fragment and a membrane C-terminal (50 kDa) fragment. Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway. |
| Function | Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. |
| Protein Name | Inactive Tyrosine-Protein Kinase 7Colon Carcinoma Kinase 4Cck-4Protein-Tyrosine Kinase 7Pseudo Tyrosine Kinase Receptor 7Tyrosine-Protein Kinase-Like 7 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinCell JunctionColocalizes With Mmp14 At Cell JunctionsAlso Localizes At The Leading Edge Of Migrating Cells |
| Alternative Antibody Names | Anti-Inactive Tyrosine-Protein Kinase 7 antibodyAnti-Colon Carcinoma Kinase 4 antibodyAnti-Cck-4 antibodyAnti-Protein-Tyrosine Kinase 7 antibodyAnti-Pseudo Tyrosine Kinase Receptor 7 antibodyAnti-Tyrosine-Protein Kinase-Like 7 antibodyAnti-PTK7 antibodyAnti-CCK4 antibody |
Information sourced from Uniprot.org
