Western blot analysis of lysates from NIH/3T3 cells, using PTGDR Rabbit polyclonal antibody (STJ114743) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-PTGDR antibody (220-359) (STJ114743)

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STJ114743
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PTGDR
Gene ID: 5729
Uniprot ID: PD2R_HUMAN
Immunogen Region: 220-359
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 220-359 of human PTGDR (NP_000944.1).
Immunogen Sequence: GAMRNLYAMHRRLQRHPRSC TRDCAEPRADGREASPQPLE ELDHLLLLALMTVLFTMCSL PVIYRAYYGAFKDVKEKNRT SEEAEDLRALRFLSVISIVD PWIFIIFRSPVFRIFFHKIF IRPLRYRSRCSNSTNMESSL
Tissue Specificity Expressed in retinal choroid, ciliary epithelium, longitudinal and circular ciliary muscles, iris, small intestine and platelet membranes.
Function Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate. Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR.
Protein Name Prostaglandin D2 Receptor
Pgd Receptor
Pgd2 Receptor
Prostanoid Dp Receptor
Database Links Reactome: R-HSA-391908
Reactome: R-HSA-418555
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Prostaglandin D2 Receptor antibody
Anti-Pgd Receptor antibody
Anti-Pgd2 Receptor antibody
Anti-Prostanoid Dp Receptor antibody
Anti-PTGDR antibody

Information sourced from Uniprot.org

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