| Function | Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. |
| Protein Name | Ph And Sec7 Domain-Containing Protein 4Exchange Factor For Adp-Ribosylation Factor Guanine Nucleotide Factor 6 BExchange Factor For Arf6 BPleckstrin Homology And Sec7 Domain-Containing Protein 4Telomeric Of Interleukin-1 Cluster Protein |
| Cellular Localisation | Cell MembraneCell ProjectionRuffle MembraneIn Interphase Associated With The Plasma MembraneIn Particular With Membrane Ruffling RegionsAccumulates In Dynamic Actin-Rich Membrane Ruffles And Microvilli-Like StructuresRecruited To Membranes Via Phosphatidylinositol Phosphate-Binding (Probable) |
| Alternative Antibody Names | Anti-Ph And Sec7 Domain-Containing Protein 4 antibodyAnti-Exchange Factor For Adp-Ribosylation Factor Guanine Nucleotide Factor 6 B antibodyAnti-Exchange Factor For Arf6 B antibodyAnti-Pleckstrin Homology And Sec7 Domain-Containing Protein 4 antibodyAnti-Telomeric Of Interleukin-1 Cluster Protein antibodyAnti-PSD4 antibodyAnti-EFA6B antibodyAnti-TIC antibody |
Information sourced from Uniprot.org
