| Post Translational Modifications | Phosphorylated by CLK1. Autophosphorylated.phosphorylation inhibits interaction with its targets, such as PRPF6 or SMARCA4. |
| Function | Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation. Connects chromatin mediated regulation of transcription and pre-mRNA splicing. During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation. Associates and probably phosphorylates SMARCA4 and NCOR1. Phosphorylates SRSF1. Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores. Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13. Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control. |
| Protein Name | Serine/Threonine-Protein Kinase Prp4 HomologPrp4 KinasePrp4 Pre-Mrna-Processing Factor 4 Homolog |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusChromosomeCentromereKinetochoreLocated Throughout The NucleusExcluding The Nucleolus But Enriched In Multiple Speckles |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Prp4 Homolog antibodyAnti-Prp4 Kinase antibodyAnti-Prp4 Pre-Mrna-Processing Factor 4 Homolog antibodyAnti-PRP4K antibodyAnti-KIAA0536 antibodyAnti-PRP4 antibodyAnti-PRP4B antibodyAnti-PRP4H antibodyAnti-PRPF4K antibody |
Information sourced from Uniprot.org
