Anti-PRAME antibody (1-509) (STJ28539)

SKU:
STJ28539

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Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-PRAME (1-509) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PRAME
Gene ID: 23532
Uniprot ID: PRAME_HUMAN
Immunogen Region: 1-509
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-509 of human PRAME (NP_006106.1).
Immunogen Sequence: MERRRLWGSIQSRYISMSVW TSPRRLVELAGQSLLKDEAL AIAALELLPRELFPPLFMAA FDGRHSQTLKAMVQAWPFTC LPLGVLMKGQHLHLETFKAV LDGLDVLLAQEVRPRRWKLQ VLDLRKNSHQDFWTVWSGNR ASLYSFPEPEAAQPMTKKRK VDGLSTEAEQPFIPVEVLVD LFLKEGACDELFSYLIEKVK
Tissue Specificity Expressed in testis. Detected in samples of kidney, brain and skin.
Function Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation. The CRL2(PRAME) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding. In the nucleus, the CRL2(PRAME) complex is recruited to epigenetically and transcriptionally active promoter regions bound by nuclear transcription factor Y (NFY) and probably plays a role in chromstin regulation. Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG: prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.
Protein Name Melanoma Antigen Preferentially Expressed In Tumors
Opa-Interacting Protein 4
Oip-4
Preferentially Expressed Antigen Of Melanoma
Cellular Localisation Nucleus
Chromosome
Cytoplasm
Golgi Apparatus
Cell Membrane
Associates With Chromatin
Specifically Enriched At Transcriptionally Active Promoters That Are Also Bound By Nuclear Transcription Factor Y (Composed Of Nfya
Nfyb And Nfyc) And At Enhancers
Recruited To The Golgi Apparatus In Response To Interferon Gamma (Ifng) Treatment
Alternative Antibody Names Anti-Melanoma Antigen Preferentially Expressed In Tumors antibody
Anti-Opa-Interacting Protein 4 antibody
Anti-Oip-4 antibody
Anti-Preferentially Expressed Antigen Of Melanoma antibody
Anti-PRAME antibody
Anti-MAPE antibody
Anti-OIP4 antibody

Information sourced from Uniprot.org

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