| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PPP3CB |
| Gene ID: | 5532 |
| Uniprot ID: | PP2BB_HUMAN |
| Immunogen Region: | 286-525 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 286-525 of human PPP3CB (NP_001135825.1). |
| Immunogen Sequence: | IIRAHEAQDAGYRMYRKSQT TGFPSLITIFSAPNYLDVYN NKAAVLKYENNVMNIRQFNC SPHPYWLPNFMDVFTWSLPF VGEKVTEMLVNVLSICSDDE LMTEGEDQFDVGSAAARKEI IRNKIRAIGKMARVFSVLRE ESESVLTLKGLTPTGMLPSG VLAGGRQTLQSATVEAIEAE KAIRGFSPPHRICSFEEAKG LDRINERMPPRKDAVQQDGF NSLNTAHATENHGTGNHTA |
| Function | Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates TFEB in response to lysosomal Ca(2+) release, resulting in TFEB nuclear translocation and stimulation of lysosomal biogenesis. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB. May play a role in skeletal muscle fiber type specification. |
| Protein Name | Serine/Threonine-Protein Phosphatase 2b Catalytic Subunit Beta IsoformCam-Prp Catalytic SubunitCalmodulin-Dependent Calcineurin A Subunit Beta IsoformCna Beta |
| Database Links | Reactome: R-HSA-180024Reactome: R-HSA-2025928Reactome: R-HSA-2871809Reactome: R-HSA-4086398Reactome: R-HSA-5607763Reactome: R-HSA-9010642 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Phosphatase 2b Catalytic Subunit Beta Isoform antibodyAnti-Cam-Prp Catalytic Subunit antibodyAnti-Calmodulin-Dependent Calcineurin A Subunit Beta Isoform antibodyAnti-Cna Beta antibodyAnti-PPP3CB antibodyAnti-CALNA2 antibodyAnti-CALNB antibodyAnti-CNA2 antibody |
Information sourced from Uniprot.org