| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PPP1CB (1-327) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PPP1CB |
| Gene ID: |
5500 |
| Uniprot ID: |
PP1B_HUMAN |
| Immunogen Region: |
1-327 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-327 of human PP1 beta (NP_002700.1). |
| Immunogen Sequence: |
MADGELNVDSLITRLLEVRG CRPGKIVQMTEAEVRGLCIK SREIFLSQPILLELEAPLKI CGDIHGQYTDLLRLFEYGGF PPEANYLFLGDYVDRGKQSL ETICLLLAYKIKYPENFFLL RGNHECASINRIYGFYDECK RRFNIKLWKTFTDCFNCLPI AAIVDEKIFCCHGGLSPDLQ SMEQIRRIMRPTDVPDTGLL CDLLWSDPDKDVQGWGENDR GVSFTFGADVVSKFLNRHD |
| Function | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective. |
| Protein Name | Serine/Threonine-Protein Phosphatase Pp1-Beta Catalytic SubunitPp-1bPpp1cd |
| Database Links | Reactome: R-HSA-163560Reactome: R-HSA-2173788Reactome: R-HSA-2565942Reactome: R-HSA-400253Reactome: R-HSA-5625740Reactome: R-HSA-5625900Reactome: R-HSA-5627117Reactome: R-HSA-5627123Reactome: R-HSA-5673000Reactome: R-HSA-9726840Reactome: R-HSA-9726842 |
| Cellular Localisation | CytoplasmNucleusNucleoplasmNucleolusHighly Mobile In Cells And Can Be Relocalized Through Interaction With Targeting SubunitsIn The Presence Of Ppp1r8 Relocalizes From The Nucleus To Nuclear Speckles |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Phosphatase Pp1-Beta Catalytic Subunit antibodyAnti-Pp-1b antibodyAnti-Ppp1cd antibodyAnti-PPP1CB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
