| Host: |
Rabbit |
| Applications: |
IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Pou Domain-Class 4-Transcription Factor 1 is suitable for use in Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
POU4F1 |
| Gene ID: |
5457 |
| Uniprot ID: |
PO4F1_HUMAN |
| Immunogen: |
Recombinant protein of human POU4F1. |
| Tissue Specificity | Expressed in the brain and the retina. Present in the developing brain, spinal cord and eye. |
| Function | Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor. Ativates BCL2 expression and protects neuronal cells from apoptosis (via the N-terminal domain). Induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins. Exerts its major developmental effects in somatosensory neurons and in brainstem nuclei involved in motor control. Stimulates the binding affinity of the nuclear estrogene receptor ESR1 to DNA estrogen response element (ERE), and hence modulates ESR1-induced transcriptional activity. May positively regulate POU4F2 and POU4F3. Regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Plays a role in TNFSF11-mediated terminal osteoclast differentiation. Negatively regulates its own expression interacting directly with a highly conserved autoregulatory domain surrounding the transcription initiation site. Isoform 2: Able to act as transcription factor, cannot regulate the expression of the same subset of genes than isoform 1. Does not have antiapoptotic effect on neuronal cells. |
| Protein Name | Pou Domain - Class 4 - Transcription Factor 1Brain-Specific Homeobox/Pou Domain Protein 3aBrain-3aBrn-3aHomeobox/Pou Domain Protein Rdc-1Oct-T1 |
| Database Links | Reactome: R-HSA-6804759 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Pou Domain - Class 4 - Transcription Factor 1 antibodyAnti-Brain-Specific Homeobox/Pou Domain Protein 3a antibodyAnti-Brain-3a antibodyAnti-Brn-3a antibodyAnti-Homeobox/Pou Domain Protein Rdc-1 antibodyAnti-Oct-T1 antibodyAnti-POU4F1 antibodyAnti-BRN3A antibodyAnti-RDC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
