| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-POSTN (472-751) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
POSTN |
| Gene ID: |
10631 |
| Uniprot ID: |
POSTN_HUMAN |
| Immunogen Region: |
472-751 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 472-751 of human POSTN (NP_001129408.1). |
| Immunogen Sequence: |
CMEKGSKQGRNGAIHIFREI IKPAEKSLHEKLKQDKRFST FLSLLEAADLKELLTQPGDW TLFVPTNDAFKGMTSEEKEI LIRDKNALQNIILYHLTPGV FIGKGFEPGVTNILKTTQGS KIFLKEVNDTLLVNELKSKE SDIMTTNGVIHVVDKLLYPA DTPVGNDQLLEILNKLIKYI QIKFVRGSTFKEIPVTVYKP IIKKYTKIIDGVPVEITEKE TREERIITGPEIKYTRIST |
| Tissue Specificity | Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus, thyroid tissue and breast. Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor. Overexpressed in breast cancers. |
| Post Translational Modifications | Gamma-carboxylation is controversial. Gamma-carboxyglutamated.gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation.this may be required for calcium binding. According to a more recent report, does not contain vitamin K-dependent gamma-carboxyglutamate residues. |
| Function | Induces cell attachment and spreading and plays a role in cell adhesion. Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX. |
| Protein Name | PeriostinPnOsteoblast-Specific Factor 2Osf-2 |
| Cellular Localisation | Golgi ApparatusSecretedExtracellular SpaceExtracellular MatrixColocalizes With Bmp1 In The Golgi |
| Alternative Antibody Names | Anti-Periostin antibodyAnti-Pn antibodyAnti-Osteoblast-Specific Factor 2 antibodyAnti-Osf-2 antibodyAnti-POSTN antibodyAnti-OSF2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
