| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-POLR3B (680-900) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
POLR3B |
| Gene ID: |
55703 |
| Uniprot ID: |
RPC2_HUMAN |
| Immunogen Region: |
680-900 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 680-900 of human POLR3B (NP_060552.4). |
| Immunogen Sequence: |
SPRNTYQCAMGKQAMGTIGY NQRNRIDTLMYLLAYPQKPM VKTKTIELIEFEKLPAGQNA TVAVMSYSGYDIEDALVLNK ASLDRGFGRCLVYKNAKCTL KRYTNQTFDKVMGPMLDAAT RKPIWRHEILDADGICSPGE KVENKQVLVNKSMPTVTQIP LEGSNVPQQPQYKDVPITYK GATDSYIEKVMISSNAEDAF LIKMLLRQTRRPEIGDKFSS R |
| Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. |
| Protein Name | Dna-Directed Rna Polymerase Iii Subunit Rpc2Rna Polymerase Iii Subunit C2C128Dna-Directed Rna Polymerase Iii 127.6 Kda PolypeptideDna-Directed Rna Polymerase Iii Subunit B |
| Database Links | Reactome: R-HSA-1834949Reactome: R-HSA-73780Reactome: R-HSA-73980Reactome: R-HSA-749476Reactome: R-HSA-76061Reactome: R-HSA-76066Reactome: R-HSA-76071 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Dna-Directed Rna Polymerase Iii Subunit Rpc2 antibodyAnti-Rna Polymerase Iii Subunit C2 antibodyAnti-C128 antibodyAnti-Dna-Directed Rna Polymerase Iii 127.6 Kda Polypeptide antibodyAnti-Dna-Directed Rna Polymerase Iii Subunit B antibodyAnti-POLR3B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
