| Tissue Specificity | Expressed in heart, lung, muscle and brain. |
| Function | Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure. |
| Protein Name | Proline-Rich Nuclear Receptor Coactivator 2 |
| Database Links | Reactome: R-HSA-975957 |
| Cellular Localisation | NucleusCytoplasmP-Body |
| Alternative Antibody Names | Anti-Proline-Rich Nuclear Receptor Coactivator 2 antibodyAnti-PNRC2 antibodyAnti-HSPC208 antibody |
Information sourced from Uniprot.org
