Host: |
Rabbit |
Applications: |
WB/IP |
Reactivity: |
Human/Mouse |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit polyclonal antibody anti-PNP (1-289) is suitable for use in Western Blot and Immunoprecipitation research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
Purification: |
Affinity purification |
Dilution Range: |
WB 1:500-1:2000IP 1:50-1:100 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
PNP |
Gene ID: |
4860 |
Uniprot ID: |
PNPH_HUMAN |
Immunogen Region: |
1-289 |
Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-289 of human PNP (NP_000261.2). |
Immunogen Sequence: |
MENGYTYEDYKNTAEWLLSH TKHRPQVAIICGSGLGGLTD KLTQAQIFDYGEIPNFPRST VPGHAGRLVFGFLNGRACVM MQGRFHMYEGYPLWKVTFPV RVFHLLGVDTLVVTNAAGGL NPKFEVGDIMLIRDHINLPG FSGQNPLRGPNDERFGDRFP AMSDAYDRTMRQRALSTWKQ MGEQRELQEGTYVMVAGPSF ETVAECRVLQKLGADAVGMS TVPEVIVARHCGLRVFGFS |
Tissue Specificity | Expressed in red blood cells.overexpressed in red blood cells (cytoplasm) of patients with hereditary non-spherocytic hemolytic anemia of unknown etiology. |
Function | Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine. |
Protein Name | Purine Nucleoside PhosphorylasePnpInosine PhosphorylaseInosine-Guanosine Phosphorylase |
Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-74217Reactome: R-HSA-74259Reactome: R-HSA-9735763Reactome: R-HSA-9755088 |
Cellular Localisation | Cytoplasm |
Alternative Antibody Names | Anti-Purine Nucleoside Phosphorylase antibodyAnti-Pnp antibodyAnti-Inosine Phosphorylase antibodyAnti-Inosine-Guanosine Phosphorylase antibodyAnti-PNP antibodyAnti-NP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance