| Host: |
Rabbit |
| Applications: |
WB/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PLSCR3 |
| Gene ID: |
57048 |
| Uniprot ID: |
PLS3_HUMAN |
| Immunogen Region: |
1-295 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-295 of human PLSCR3 (NP_065093.2). |
| Immunogen Sequence: |
MAGYLPPKGYAPSPPPPYPV TPGYPEPALHPGPGQAPVPA QVPAPAPGFALFPSPGPVAL GSAAPFLPLPGVPSGLEFLV QIDQILIHQKAERVETFLGW ETCNRYELRSGAGQPLGQAA EESNCCARLCCGARRPLRVR LADPGDREVLRLLRPLHCGC SCCPCGLQEMEVQAPPGTTI GHVLQTWHPFLPKFSIQDAD RQTVLRVVGPCWTCGCGTDT NFEVKTRDESRSVGRISKQ |
| Tissue Specificity | Expressed in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine and peripheral blood lymphocytes. Not detected in testis, brain and liver. |
| Post Translational Modifications | Phosphorylation at Thr-21 by PKC/PRKCD upon apoptotic stimuli enhances phospholipid scramblase activity. Palmitoylation regulates its localization to the cell membrane or the nucleus.trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus. |
| Function | Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of the phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer membrane of the mitochondria. Plays an important role in mitochondrial respiratory function, morphology, and apoptotic response. Mediates the translocation of cardiolipin from the mitochondrial inner membrane to outer membrane enhancing t-Bid induced cytochrome c release and apoptosis. Enhances TNFSF10-induced apoptosis by regulating the distribution of cardiolipin in the mitochondrial membrane resulting in increased release of apoptogenic factors and consequent amplification of the activity of caspases. Regulates cardiolipin de novo biosynthesis and its resynthesis. |
| Protein Name | Phospholipid Scramblase 3Pl Scramblase 3Ca(2+-Dependent Phospholipid Scramblase 3 |
| Cellular Localisation | Mitochondrion MembraneSingle-Pass Type Ii Membrane ProteinMitochondrion Inner MembraneNucleusPalmitoylation Regulates Its Localization To The Cell Membrane Or The NucleusTrafficking To The Cell Membrane Is Dependent Upon Palmitoylation Whereas In The Absence Of PalmitoylationLocalizes To The Nucleus |
| Alternative Antibody Names | Anti-Phospholipid Scramblase 3 antibodyAnti-Pl Scramblase 3 antibodyAnti-Ca(2+-Dependent Phospholipid Scramblase 3 antibodyAnti-PLSCR3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
