| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PLEKHA7 |
| Gene ID: | 144100 |
| Uniprot ID: | PKHA7_HUMAN |
| Immunogen Region: | 1-300 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PLEKHA7 (NP_778228.3). |
| Immunogen Sequence: | MAAATVGRDTLPEHWSYGVC RDGRVFFINDQLRCTTWLHP RTGEPVNSGHMIRSDLPRGW EEGFTEEGASYFIDHNQQTT AFRHPVTGQFSPENSEFILQ EEPNPHMSKQDRNQRPSSMV SETSTAGTASTLEAKPGPKI IKSSSKVHSFGKRDQAIRRN PNVPVVVRGWLHKQDSSGMR LWKRRWFVLADYCLFYYKDS REEAVLGSIPLPSYVISPVA PEDRISRKYSFKAVHTGMR |
| Function | Required for zonula adherens biogenesis and maintenance. Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site. Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33. |
| Protein Name | Pleckstrin Homology Domain-Containing Family A Member 7Ph Domain-Containing Family A Member 7 |
| Cellular Localisation | Cell JunctionAdherens JunctionCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeLocalizes To Zonula AdherensRecruited Via Its Interaction With Ctnnd1 |
| Alternative Antibody Names | Anti-Pleckstrin Homology Domain-Containing Family A Member 7 antibodyAnti-Ph Domain-Containing Family A Member 7 antibodyAnti-PLEKHA7 antibody |
Information sourced from Uniprot.org