| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PLCL1 (110-350) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PLCL1 |
| Gene ID: |
5334 |
| Uniprot ID: |
PLCL1_HUMAN |
| Immunogen Region: |
110-350 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 110-350 of human PLCL1 (NP_006217.3). |
| Immunogen Sequence: |
DCISFMQAGCELKKVRPNSR IYNRFFTLDTDLQALRWEPS KKDLEKAKLDISAIKEIRLG KNTETFRNNGLADQICEDCA FSILHGENYESLDLVANSAD VANIWVSGLRYLVSRSKQPL DFMEGNQNTPRFMWLKTVFE AADVDGNGIMLEDTSVELIK QLNPTLKEAKIRLKFKEIQK SKEKLTTRVTEEEFCEAFCE LCTRPEVYFLLVQISKNKEY LDANDLMLFLEAEQGVTHI |
| Tissue Specificity | Expressed in a variety of fetal and adult organs including brain, lung and kidney. Its expression was greatly reduced in small and non-small cell lung carcinoma. Isoform 1 is predominantly expressed in brain. |
| Post Translational Modifications | Phosphorylated by the catalytic subunit of PKA. Phosphorylation of Thr-93 resulted in dissociation of PPP1C from PRIP1. |
| Function | Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor. Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C. |
| Protein Name | Inactive Phospholipase C-Like Protein 1Plc-L1Phospholipase C-Deleted In Lung CarcinomaPhospholipase C-Related But Catalytically Inactive ProteinPrip |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Inactive Phospholipase C-Like Protein 1 antibodyAnti-Plc-L1 antibodyAnti-Phospholipase C-Deleted In Lung Carcinoma antibodyAnti-Phospholipase C-Related But Catalytically Inactive Protein antibodyAnti-Prip antibodyAnti-PLCL1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
