| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PIWIL3 (40-320) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PIWIL3 |
| Gene ID: |
440822 |
| Uniprot ID: |
PIWL3_HUMAN |
| Immunogen Region: |
40-320 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 40-320 of human PIWIL3 (NP_001242904.1). |
| Immunogen Sequence: |
QLQSTPRPLQEEVPVVRPLQ PRAARGGAGGGAQSQGVKEP GPEAGLHTAPLQERRIGGVF QDLVVNTRQDMKHVKDSKTG SEGTVVQLLANHFRVISRPQ WVAYKYNVDYKPDIEDGNLR TILLDQHRRKFGERHIFDGN SLLLSRPLKERRVEWLSTTK DKNIVKITVEFSKELTPTSP DCLRYYNILFRRTFKLLDFE QVGRNYYTKKKAIQLYRHGT SLEIWLGYVTSVLQYENSI |
| Tissue Specificity | Expressed in testis. |
| Function | May play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. |
| Protein Name | Piwi-Like Protein 3 |
| Cellular Localisation | CytoplasmProbable Component Of The Meiotic NuageAlso Named P GranuleA Germ-Cell-Specific Organelle Required To Repress Transposon Activity During Meiosis |
| Alternative Antibody Names | Anti-Piwi-Like Protein 3 antibodyAnti-PIWIL3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
