| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PINX1 (127-328) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PINX1 |
| Gene ID: |
54984 |
| Uniprot ID: |
PINX1_HUMAN |
| Immunogen Region: |
127-328 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 127-328 of human PINX1 (NP_060354.4). |
| Immunogen Sequence: |
MKFTKGKDLSSRSKTDLDCI FGKRQSKKTPEGDASPSTPE ENETTTTSAFTIQEYFAKRM AALKNKPQVPVPGSDISETQ VERKRGKKRNKEATGKDVES YLQPKAKRHTEGKPERAEAQ ERVAKKKSAPAEEQLRGPCW DQSSKASAQDAGDHVQPPEG RDFTLKPKKRRGKKKLQKPV EIAEDATLEETLVKKKKKKD SK |
| Tissue Specificity | Ubiquitous.expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines. |
| Post Translational Modifications | Cleaved by enterovirus protease 3C to promote apoptosis. |
| Function | Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. |
| Protein Name | Pin2/Terf1-Interacting Telomerase Inhibitor 1Liver-Related Putative Tumor SuppressorPin2-Interacting Protein X1Protein 67-11-3Trf1-Interacting Protein 1 |
| Cellular Localisation | NucleusNucleolusChromosomeTelomereCentromereKinetochoreLocalizes In NucleoliAt Telomere Speckles And To The Outer Plate Of KinetochoresLocalization To The Kinetochore Is Mediated By Its Central Region And Depends On Ndc80 And Cenpe |
| Alternative Antibody Names | Anti-Pin2/Terf1-Interacting Telomerase Inhibitor 1 antibodyAnti-Liver-Related Putative Tumor Suppressor antibodyAnti-Pin2-Interacting Protein X1 antibodyAnti-Protein 67-11-3 antibodyAnti-Trf1-Interacting Protein 1 antibodyAnti-PINX1 antibodyAnti-LPTL antibodyAnti-LPTS antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
