| Tissue Specificity | Predominantly detected in hemopoietic tissues and is expressed by monocytes, macrophages, and granulocytes, but not by lymphocytes. Also strongly expressed by dendritic cells (DC).preferentially by CD14+/CD1a- DC derived from CD34+ progenitors. Also expressed by CD11c+ blood and tonsil DC, but not by CD11c- DC precursors. |
| Post Translational Modifications | N- and O-glycosylated. only N-glycosylated. Phosphorylated on tyrosine residues. |
| Function | Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP. (Microbial infection) Acts as an entry co-receptor for herpes simplex virus 1. |
| Protein Name | Paired Immunoglobulin-Like Type 2 Receptor AlphaCell Surface Receptor Fdf03Inhibitory Receptor Pilr-Alpha |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Cell MembraneIsoform 3: SecretedIsoform 4: Secreted |
| Alternative Antibody Names | Anti-Paired Immunoglobulin-Like Type 2 Receptor Alpha antibodyAnti-Cell Surface Receptor Fdf03 antibodyAnti-Inhibitory Receptor Pilr-Alpha antibodyAnti-PILRA antibody |
Information sourced from Uniprot.org
