| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PI4K2A (131-479) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PI4K2A |
| Gene ID: |
55361 |
| Uniprot ID: |
P4K2A_HUMAN |
| Immunogen Region: |
131-479 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 131-479 of human PI4K2A (NP_060895.1). |
| Immunogen Sequence: |
YQGSSGSYFVKDPQGRIIAV FKPKNEEPYGHLNPKWTKWL QKLCCPCCFGRDCLVLNQGY LSEAGASLVDQKLELNIVPR TKVVYLASETFNYSAIDRVK SRGKRLALEKVPKVGQRFNR IGLPPKVGSFQLFVEGYKDA DYWLRRFEAEPLPENTNRQL LLQFERLVVLDYIIRNTDRG NDNWLIKYDCPMDSSSSRDT DWVVVKEPVIKVAAIDNGLA FPLKHPDSWRAYPFYWAWL |
| Tissue Specificity | Widely expressed. Highest expression is observed in kidney, brain, heart, skeletal muscle, and placenta and lowest expression is observed in colon, thymus, and small intestine. |
| Post Translational Modifications | Palmitoylated by ZDHHC3 and ZDHHC7 in the CCPCC motif. Palmitoylation is cholesterol-dependent, and required for TGN localization. Ubiquitinated by ITCH.this does not lead to proteasomal degradation. |
| Function | Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). |
| Protein Name | Phosphatidylinositol 4-Kinase Type 2-AlphaPhosphatidylinositol 4-Kinase Type Ii-Alpha |
| Database Links | Reactome: R-HSA-1660499Reactome: R-HSA-1660514Reactome: R-HSA-1660516 |
| Cellular Localisation | Golgi ApparatusTrans-Golgi Network MembraneLipid-AnchorMembrane RaftCell ProjectionDendritePresynaptic Cell MembraneSynapseSynaptosomeMitochondrionEndosomeCytoplasmic VesicleMembraneCell MembranePerikaryonNeuron ProjectionFound In Subdomains Of The Plasma Membrane Termed Non-Caveolar Membrane RaftsTransported From Neuronal Cell Body To Neuron Projections And Neurite Tips In A Bloc-1- And Ap-3-Complexes-Dependent Manner |
| Alternative Antibody Names | Anti-Phosphatidylinositol 4-Kinase Type 2-Alpha antibodyAnti-Phosphatidylinositol 4-Kinase Type Ii-Alpha antibodyAnti-PI4K2A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
