| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phospho-Non-receptor tyrosine-protein kinase TYK2-Tyr292 is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TYK2 |
| Gene ID: | 7297 |
| Uniprot ID: | TYK2_HUMAN |
| Specificity: | This antibody detects endogenous levels of Human Tyk 2 (Phospho Tyr292) |
| Immunogen: | Synthesized peptide derived from human Tyk 2 (Phospho Tyr292) |
| Tissue Specificity | Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines. |
| Post Translational Modifications | Phosphorylated. Phosphorylation by JAK1 at Tyr-1054 and Tyr-1055 induces kinase activation. |
| Function | Tyrosine kinase of the non-receptor type involved in numerous cytokines and interferons signaling, which regulates cell growth, development, cell migration, innate and adaptive immunity. Plays both structural and catalytic roles in numerous interleukins and interferons (IFN-alpha/beta) signaling. Associates with heterodimeric cytokine receptor complexes and activates STAT family members including STAT1, STAT3, STAT4 or STAT6. The heterodimeric cytokine receptor complexes are composed of (1) a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1), and (2) a second receptor chain associated either with JAK1 or JAK2. In response to cytokine-binding to receptors, phosphorylates and activates receptors (IFNAR1, IL12RB1, IL10RB or IL13RA1), creating docking sites for STAT members. In turn, recruited STATs are phosphorylated by TYK2 (or JAK1/JAK2 on the second receptor chain), form homo- and heterodimers, translocate to the nucleus, and regulate cytokine/growth factor responsive genes. Negatively regulates STAT3 activity by promototing phosphorylation at a specific tyrosine that differs from the site used for signaling. |
| Protein Name | Non-Receptor Tyrosine-Protein Kinase Tyk2 |
| Database Links | Reactome: R-HSA-1059683 Reactome: R-HSA-110056 Reactome: R-HSA-112411 Reactome: R-HSA-449836 Reactome: R-HSA-6783783 Reactome: R-HSA-6785807 Reactome: R-HSA-6788467 Reactome: R-HSA-8854691 Reactome: R-HSA-8984722 Reactome: R-HSA-9020591 Reactome: R-HSA-9020933 Reactome: R-HSA-9020956 Reactome: R-HSA-909733 Reactome: R-HSA-912694 Reactome: R-HSA-9674555 Reactome: R-HSA-9679191 Reactome: R-HSA-9705462 Reactome: R-HSA-9705671 Reactome: R-HSA-9725370 Reactome: R-HSA-9833109 |
| Alternative Antibody Names | Anti-Non-Receptor Tyrosine-Protein Kinase Tyk2 antibody Anti-TYK2 antibody |
Information sourced from Uniprot.org