Anti-Phospho-TNNI3-Ser43 antibody (STJA0003810)

SKU:
STJA0003810-100
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat/Bovine/Canine/Non-Human Primates/Sheep/Xenopus/Zebrafish
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Phospho-Cardiac Troponin I-Ser43 is suitable for use in Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol.
Purification: This antibody was antigen affinity purified from pooled serum.
Dilution Range: WB 1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Tnni3
Gene ID: 21954
Uniprot ID: TNNI3_MOUSE
Immunogen: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser43 conjugated to KLH.
Post Translational Modifications Phosphorylated at Ser-23 and Ser-24 by PRKD1.phosphorylation reduces myofilament calcium sensitivity. Phosphorylated preferentially at Thr-32. Phosphorylation by STK4/MST1 alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylated at Ser-43 and Ser-45 by PRKCE.phosphorylation increases myocardium contractile dysfunction.
Function Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Protein Name Troponin I - Cardiac Muscle
Cardiac Troponin I
Database Links Reactome: R-MMU-390522
Reactome: -MMU-5578775
Alternative Antibody Names Anti-Troponin I - Cardiac Muscle antibody
Anti-Cardiac Troponin I antibody
Anti-Tnni3 antibody

Information sourced from Uniprot.org