| Tissue Specificity | Expressed in the brain (at protein level). Predominantly expressed in rostral, phylogenetically younger brain regions, and in some endocrine tissues. |
| Post Translational Modifications | Glycosylated. |
| Function | Calcium sensor that participates in triggering neurotransmitter release at the synapse. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner.these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes. (Microbial infection) Receptor for C.botulinum neurotoxin type B (BoNT/B, botB).interaction is improved in the presence of gangliosides. BoNT/B toxin binds to the membrane proximal vesicular domain of Syt1 (residues 32-51). (Microbial infection) Receptor for C.botulinum neurotoxin type G (BoNT/G, botG).unlike the case with BoNT/B, interaction is not improved in the presence of gangliosides. BoNT/G toxin binds to the vesicular domain of Syt1 (residues 32-53). |
| Protein Name | Synaptotagmin-1Synaptotagmin ISytiP65 |
| Database Links | Reactome: R-RNO-181429Reactome: -RNO-181430Reactome: -RNO-210500Reactome: -RNO-212676Reactome: -RNO-264642Reactome: -RNO-8856825Reactome: -RNO-8856828Reactome: -RNO-888590 |
| Cellular Localisation | Cytoplasmic VesicleSecretory Vesicle MembraneSingle-Pass Membrane ProteinSecretory VesicleSynaptic Vesicle MembraneChromaffin Granule MembraneCytoplasm |
| Alternative Antibody Names | Anti-Synaptotagmin-1 antibodyAnti-Synaptotagmin I antibodyAnti-Syti antibodyAnti-P65 antibodyAnti-Syt1 antibody |
Information sourced from Uniprot.org
