• Immunohistochemistry analysis of paraffin-embedded human brain, using Kir5.1 (Phospho-Ser417) Antibody. The picture on the right is blocked with the phospho peptide.
  • Western blot analysis of lysates from RAW264.7 cells treated with forskolin 40nM 30', using Kir5.1 (Phospho-Ser417) Antibody. The lane on the right is blocked with the phospho peptide.
  • Immunofluorescence analysis of HeLa cells, using Kir5.1 (Phospho-Ser417) Antibody. The picture on the right is blocked with the phospho peptide.

Anti-Phospho-KIR5.1-Ser416 antibody (369-418 aa) (STJ91098)

SKU:
STJ91098

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-KCNJ16-Ser416 (369-418 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:5000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunogen Region: 369-418 aa
Specificity: Phospho-KIR5.1 (S416) Polyclonal Antibody detects endogenous levels of KIR5.1 protein only when phosphorylated at S416.
Immunogen: The antiserum was produced against synthesized peptide derived from mouse Kir5.1 around the phosphorylation site of Ser417 at the amino acid range 369-418
Function Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium.as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolateral K(+) recycling in distal tubules.this process is critical for Na(+) reabsorption at the tubules.
Protein Name Inward Rectifier Potassium Channel 16
Inward Rectifier K(+ Channel Kir5.1
Potassium Channel - Inwardly Rectifying Subfamily J Member 16
Database Links Reactome: R-HSA-1296041
Reactome: R-HSA-1296067
Reactome: R-HSA-997272
Cellular Localisation Membrane
Multi-Pass Membrane Protein
Basolateral Cell Membrane
In Kidney Distal Convoluted Tubules
Located In The Basolateral Membrane In The Presence Of Kcnj10
Alternative Antibody Names Anti-Inward Rectifier Potassium Channel 16 antibody
Anti-Inward Rectifier K(+ Channel Kir5.1 antibody
Anti-Potassium Channel - Inwardly Rectifying Subfamily J Member 16 antibody
Anti-KCNJ16 antibody

Information sourced from Uniprot.org

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