• Western blot of 3T3 cell lysate showing specific immunolabeling of the ~83 kDa FAM129B protein phosphorylated at Ser679/683 in the first lane (-). Phosphospecificity is shown in the second lane (+) where immunolabeling is blocked by preadsorption of the phosphopeptide used as the antigen, but not by the corresponding non-phosphopeptide (not shown).

Anti-Phospho-FAM129B-Ser679/683 antibody (STJA0003632)

SKU:
STJA0003632-100

£454.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Non-Human Primates
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-FAM129B-Ser679/683 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol.
Purification: This antibody was antigen affinity purified from pooled serum.
Dilution Range: WB 1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: NIBAN2
Gene ID: 64855
Uniprot ID: NIBA2_HUMAN
Immunogen: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser679/683 conjugated to KLH.
Post Translational Modifications Phosphorylated at Ser-641, Ser-646, Ser-692 and Ser-696 by the BRAF/MKK/ERK signaling cascade. In melanoma cells, the C-terminal phosphorylation may prevent targeting to the plasma membrane. As apoptosis proceeds, degraded via an proteasome-independent pathway, probably by caspases.
Function May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro.
Protein Name Protein Niban 2
Meg-3
Melanoma Invasion By Erk
Minerva
Niban-Like Protein 1
Protein Fam129b
Cellular Localisation Cytoplasm
Cytosol
Cell Junction
Adherens Junction
Membrane
Lipid-Anchor
In Exponentially Growing Cells
Exclusively Cytoplasmic
Cell Membrane Localization Is Observed When Cells Reach Confluency And During Telophase
In Melanoma Cells
Targeting To The Plasma Membrane May Be Impaired By C-Terminal Phosphorylation
Alternative Antibody Names Anti-Protein Niban 2 antibody
Anti-Meg-3 antibody
Anti-Melanoma Invasion By Erk antibody
Anti-Minerva antibody
Anti-Niban-Like Protein 1 antibody
Anti-Protein Fam129b antibody
Anti-NIBAN2 antibody
Anti-C9orf88 antibody
Anti-FAM129B antibody

Information sourced from Uniprot.org

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