| Post Translational Modifications | Phosphorylated at Ser-641, Ser-646, Ser-692 and Ser-696 by the BRAF/MKK/ERK signaling cascade. In melanoma cells, the C-terminal phosphorylation may prevent targeting to the plasma membrane. As apoptosis proceeds, degraded via an proteasome-independent pathway, probably by caspases. |
| Function | May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro. |
| Protein Name | Protein Niban 2Meg-3Melanoma Invasion By ErkMinervaNiban-Like Protein 1Protein Fam129b |
| Cellular Localisation | CytoplasmCytosolCell JunctionAdherens JunctionMembraneLipid-AnchorIn Exponentially Growing CellsExclusively CytoplasmicCell Membrane Localization Is Observed When Cells Reach Confluency And During TelophaseIn Melanoma CellsTargeting To The Plasma Membrane May Be Impaired By C-Terminal Phosphorylation |
| Alternative Antibody Names | Anti-Protein Niban 2 antibodyAnti-Meg-3 antibodyAnti-Melanoma Invasion By Erk antibodyAnti-Minerva antibodyAnti-Niban-Like Protein 1 antibodyAnti-Protein Fam129b antibodyAnti-NIBAN2 antibodyAnti-C9orf88 antibodyAnti-FAM129B antibody |
Information sourced from Uniprot.org
