| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phospho-Ephrin type-A receptor 3-Tyr602 is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EPHA3 |
| Gene ID: | 2042 |
| Uniprot ID: | EPHA3_HUMAN |
| Specificity: | This antibody detects endogenous levels of Human, Mouse, Rat EPHA3 (Phospho Tyr602) |
| Immunogen: | Synthesized peptide derived from human EPHA3 (Phospho Tyr602) |
| Tissue Specificity | Widely expressed. Highest level in placenta. |
| Post Translational Modifications | Autophosphorylates upon activation by EFNA5. Phosphorylation on Tyr-602 mediates interaction with NCK1. Dephosphorylated by PTPN1. |
| Function | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. |
| Protein Name | Ephrin Type-A Receptor 3 Eph-Like Kinase 4 Ek4 Hek4 Hek Human Embryo Kinase Tyrosine-Protein Kinase Tyro4 Tyrosine-Protein Kinase Receptor Etk1 Eph-Like Tyrosine Kinase 1 |
| Database Links | Reactome: R-HSA-2682334 Reactome: R-HSA-3928663 Reactome: R-HSA-3928665 |
| Cellular Localisation | Isoform 1: Cell Membrane Single-Pass Type I Membrane Protein Isoform 2: Secreted |
| Alternative Antibody Names | Anti-Ephrin Type-A Receptor 3 antibody Anti-Eph-Like Kinase 4 antibody Anti-Ek4 antibody Anti-Hek4 antibody Anti-Hek antibody Anti-Human Embryo Kinase antibody Anti-Tyrosine-Protein Kinase Tyro4 antibody Anti-Tyrosine-Protein Kinase Receptor Etk1 antibody Anti-Eph-Like Tyrosine Kinase 1 antibody Anti-EPHA3 antibody Anti-ETK antibody Anti-ETK1 antibody Anti-HEK antibody Anti-TYRO4 antibody |
Information sourced from Uniprot.org