Anti-Phospho-c-Myc-T58/S62 antibody [ARC1532] (STJ11102579)

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STJ11102579

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Host: Rabbit
Applications: WB
Reactivity: Human, Rat
Short Description: Rabbit monoclonal anti-Phospho-c-Myc-T58/S62 antibody is suitable for use in Western Blot.
Note: FOR RESEARCH USE ONLY (RUO).
Clonality: Monoclonal
Clone ID: ARC1532
Conjugation: Unconjugated
Formulation: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Purification: Affinity purification
Storage Instruction: Store at-20°C. Avoid freeze/thaw cycles.
Isotype: IgG
Dilution Range: WB: 1:500-1:2000
Uniprot ID: MYC_HUMAN
Gene ID: 4609
Gene Symbol: MYC
Immunogen: A phospho specific peptide corresponding to residues surrounding T58/S62 of human c-Myc
Post Translational Modifications Phosphorylated by PRKDC. Phosphorylation at Ser-329 by PIM2 leads to the stabilization of MYC. Phosphorylation at Ser-62 by CDK2 prevents Ras-induced senescence. Phosphorylated at Ser-62 by DYRK2.this primes the protein for subsequent phosphorylation by GSK3B at Thr-58. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome. Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. In the nucleoplasm, ubiquitination is counteracted by USP28, which interacts with isoform 1 of FBXW7 (FBW7alpha), leading to its deubiquitination and preventing degradation. In the nucleolus, however, ubiquitination is not counteracted by USP28 but by USP36, due to the lack of interaction between isoform 3 of FBXW7 (FBW7gamma) and USP28, explaining the selective MYC degradation in the nucleolus. Also polyubiquitinated by the DCX(TRUSS) complex. Ubiquitinated by TRIM6 in a phosphorylation-independent manner.
Function Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CACGATG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release.
Protein Name Myc Proto-Oncogene Protein
Class E Basic Helix-Loop-Helix Protein 39
Bhlhe39
Proto-Oncogene C-Myc
Transcription Factor P64
Database Links Reactome: R-HSA-1362277
Reactome: R-HSA-2122947
Reactome: R-HSA-2173796
Reactome: R-HSA-2644606
Reactome: R-HSA-2894862
Reactome: R-HSA-4411364
Reactome: R-HSA-5687128
Reactome: R-HSA-5689880
Reactome: R-HSA-6785807
Reactome: R-HSA-69202
Reactome: R-HSA-69656
Reactome: R-HSA-8866911
Reactome: R-HSA-8951430
Reactome: R-HSA-9018519
Reactome: R-HSA-9616222
Cellular Localisation Nucleus
Nucleoplasm
Nucleolus
Alternative Antibody Names Anti-Myc Proto-Oncogene Protein antibody
Anti-Class E Basic Helix-Loop-Helix Protein 39 antibody
Anti-Bhlhe39 antibody
Anti-Proto-Oncogene C-Myc antibody
Anti-Transcription Factor P64 antibody
Anti-MYC antibody
Anti-BHLHE39 antibody

Information sourced from Uniprot.org

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