| Tissue Specificity | Widely expressed, including in liver (at protein level). |
| Post Translational Modifications | Phosphorylated by PKA on specific serine residues, leading to the formation of an active lysine demethylase complex. |
| Function | Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA. Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters. |
| Protein Name | Lysine-Specific Demethylase Phf2Grc5Phd Finger Protein 2 |
| Database Links | Reactome: R-HSA-3214842 |
| Cellular Localisation | NucleusNucleolusChromosomeCentromereKinetochore |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase Phf2 antibodyAnti-Grc5 antibodyAnti-Phd Finger Protein 2 antibodyAnti-PHF2 antibodyAnti-CENP-35 antibodyAnti-KIAA0662 antibody |
Information sourced from Uniprot.org
