| Post Translational Modifications | Glycosylated. |
| Function | Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchor proteins (GPI-AP). Has phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for the shedding of the GPI-AP CRIPTO, but not CFC1, at the cell surface. Shedding of CRIPTO modulates Nodal signaling by allowing soluble CRIPTO to act as a Nodal coreceptor on other cells. Also indirectly involved in the translocation of RAC1 from the cytosol to the plasma membrane by maintaining the steady state amount of CAV1-enriched plasma membrane subdomains, stabilizing RAC1 at the plasma membrane. In contrast to myomaker (TMEM8C), has no fusogenic activity. |
| Protein Name | Post-Gpi Attachment To Proteins Factor 6Gpi Processing Phospholipase A2Gpi-Pla2Protein M83Transmembrane Protein 6Transmembrane Protein 8Transmembrane Protein 8a |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinLysosome Membrane |
| Alternative Antibody Names | Anti-Post-Gpi Attachment To Proteins Factor 6 antibodyAnti-Gpi Processing Phospholipase A2 antibodyAnti-Gpi-Pla2 antibodyAnti-Protein M83 antibodyAnti-Transmembrane Protein 6 antibodyAnti-Transmembrane Protein 8 antibodyAnti-Transmembrane Protein 8a antibodyAnti-PGAP6 antibodyAnti-TMEM6 antibodyAnti-TMEM8 antibodyAnti-TMEM8A antibody |
Information sourced from Uniprot.org
