| Post Translational Modifications | Both isoform 1 and isoform 2 are phosphorylated by the RIPK1/RIPK3 complex under necrotic conditions. This phosphorylation increases PGAM5 phosphatase activity. Proteolytically cleaved by PARL in response to loss of mitochondrial membrane potential. |
| Function | Mitochondrial serine/threonine phosphatase that dephosphorylates various substrates and thus plays a role in different biological processes including cellular senescence or mitophagy. Modulates cellular senescence by regulating mitochondrial dynamics. Mechanistically, participates in mitochondrial fission through dephosphorylating DNM1L/DRP1. Additionally, dephosphorylates MFN2 in a stress-sensitive manner and consequently protects it from ubiquitination and degradation to promote mitochondrial network formation. Regulates mitophagy independent of PARKIN by interacting with and dephosphorylating FUNDC1, which interacts with LC3. Regulates anti-oxidative response by forming a tertiary complex with KEAP1 and NRF2. Regulates necroptosis by acting as a RIPK3 target and recruiting the RIPK1-RIPK3-MLKL necrosis 'attack' complex to mitochondria. |
| Protein Name | Serine/Threonine-Protein Phosphatase Pgam5 - MitochondrialBcl-Xl-Binding Protein V68Phosphoglycerate Mutase Family Member 5 |
| Database Links | Reactome: R-HSA-8934903 Q96HS1-2Reactome: R-HSA-9861718 Q96HS1-1 |
| Cellular Localisation | Mitochondrion Outer MembraneSingle-Pass Membrane ProteinMitochondrion Inner MembraneIsoform 2 Overexpression Results In The Formation Of Disconnected Punctuate Mitochondria Distributed Throughout The CytoplasmIsoform 1 Overexpression Results In The Clustering Of Mitochondria Around The Nucleus |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Phosphatase Pgam5 - Mitochondrial antibodyAnti-Bcl-Xl-Binding Protein V68 antibodyAnti-Phosphoglycerate Mutase Family Member 5 antibodyAnti-PGAM5 antibody |
Information sourced from Uniprot.org
