| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PEDF/SERPINF1 (301-400) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SERPINF1 |
| Gene ID: |
5176 |
| Uniprot ID: |
PEDF_HUMAN |
| Immunogen Region: |
301-400 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 301-400 of human PEDF/SERPINF1 (NP_002606.3). |
| Immunogen Sequence: |
IDRELKTVQAVLTVPKLKLS YEGEVTKSLQEMKLQSLFDS PDFSKITGKPIKLTQVEHRA GFEWNEDGAGTTPSPGLQPA HLTFPLDYHLNQPFIFVLRD |
| Tissue Specificity | Retinal pigment epithelial cells and blood plasma. |
| Post Translational Modifications | The N-terminus is blocked. Extracellular phosphorylation enhances antiangiogenic activity. N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan. |
| Function | Neurotrophic protein.induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. |
| Protein Name | Pigment Epithelium-Derived FactorPedfCell Proliferation-Inducing Gene 35 ProteinEpc-1Serpin F1 |
| Cellular Localisation | SecretedMelanosomeEnriched In Stage I Melanosomes |
| Alternative Antibody Names | Anti-Pigment Epithelium-Derived Factor antibodyAnti-Pedf antibodyAnti-Cell Proliferation-Inducing Gene 35 Protein antibodyAnti-Epc-1 antibodyAnti-Serpin F1 antibodyAnti-SERPINF1 antibodyAnti-PEDF antibodyAnti-PIG35 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
