| Tissue Specificity | Ubiquitously expressed (at protein level). Highly expressed in all the regions of central nerve system except the spinal cord. Also expressed at high level in liver and testis. In fetus, it is weakly expressed in all organs except brain. |
| Function | Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP and therefore plays a role in vitamin B6 metabolism. Also functions as a protein serine phosphatase that specifically dephosphorylates 'Ser-3' in proteins of the actin-depolymerizing factor (ADF)/cofilin family like CFL1 and DSTN. Thereby, regulates cofilin-dependent actin cytoskeleton reorganization, being required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phosphothreonines in LIMK1. Does not dephosphorylate peptides containing phosphotyrosine. |
| Protein Name | ChronophinPyridoxal Phosphate PhosphatasePlp Phosphatase |
| Cellular Localisation | CytoplasmCytosolCytoskeletonCell ProjectionRuffle MembranePeripheral Membrane ProteinCytoplasmic SideLamellipodium MembraneCell MembraneColocalizes With The Actin Cytoskeleton In Membrane Ruffles And LamellipodiaDiffusely Distributed Throughout The Cytosol During Pro-Metaphase And MetaphaseDetected At The Dynamic Cell Poles During TelophaseDetected At The Cleavage Furrow And Contractile Ring During CytokinesisTransiently Detected At The Plasma Membrane In Late Stages Of CytokinesisDetected At The Midbody |
| Alternative Antibody Names | Anti-Chronophin antibodyAnti-Pyridoxal Phosphate Phosphatase antibodyAnti-Plp Phosphatase antibodyAnti-PDXP antibodyAnti-CIN antibodyAnti-PLP antibodyAnti-PLPP antibody |
Information sourced from Uniprot.org
