| Function | Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart. Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory. |
| Protein Name | High Affinity Cgmp-Specific 3' -5'-Cyclic Phosphodiesterase 9a |
| Database Links | Reactome: R-HSA-418457 |
| Cellular Localisation | Isoform Pde9a1: Cell ProjectionRuffle MembraneCytoplasmPerinuclear RegionGolgi ApparatusEndoplasmic ReticulumCell MembraneSarcolemmaIsoform Pde9a2: Cell ProjectionIsoform Pde9a3: CytoplasmIsoform Pde9a17: Cytoplasm |
| Alternative Antibody Names | Anti-High Affinity Cgmp-Specific 3' -5'-Cyclic Phosphodiesterase 9a antibodyAnti-PDE9A antibody |
Information sourced from Uniprot.org
