| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-High affinity cGMP-specific 3 NA, 5 cyclic phosphodiesterase 9A is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PDE9A |
| Gene ID: |
5152 |
| Uniprot ID: |
PDE9A_HUMAN |
| Specificity: |
This antibody detects endogenous levels of PDE9A at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human PDE9A |
| Function | Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart. Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory. |
| Protein Name | High Affinity Cgmp-Specific 3' -5'-Cyclic Phosphodiesterase 9a |
| Database Links | Reactome: R-HSA-418457 |
| Cellular Localisation | Isoform Pde9a1: Cell ProjectionRuffle MembraneCytoplasmPerinuclear RegionGolgi ApparatusEndoplasmic ReticulumCell MembraneSarcolemmaIsoform Pde9a2: Cell ProjectionIsoform Pde9a3: CytoplasmIsoform Pde9a17: Cytoplasm |
| Alternative Antibody Names | Anti-High Affinity Cgmp-Specific 3' -5'-Cyclic Phosphodiesterase 9a antibodyAnti-PDE9A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
